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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LOXAPINE

LOXAPINE


ATC N05AH01

NERVOUS SYSTEM
ANXIOLYTIC
DIBENZOXAZEPINE ANTIPSYCHOTIC AGENTS
DOPAMINE ANTAGONISTS
TREATMENT OF SCHIZOPHRENIA

ORAL INJECTION INHALATION

Cmax 415 NANOMOLAR

Tmax 1.88 HOUR

VD 509.8 LITER (EQN)

Cl 48.4 LITER / HOUR

HT 7.3 HOUR

D(2) DOPAMINE RECEPTOR
SEROTONIN 5-HT2 RECEPTOR (PMID24937085)

D2-LIKE DOPAMINE RECEPTOR ANTAGONIST CHEMBL2331075 D2-LIKE DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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