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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PIMOZIDE
| PIMOZIDE | NERVOUS SYSTEM | ORAL | Tmax 7 HOUR F 50 PERCENT VD 1833 LITER (65 KILOGRAM) Cl 16 LITER / HOUR (65 KILOGRAM) HT 55 HOUR SOLUBILITY IN WATER LESS THAN 0.01 MILLIGRAM / MILLILITER | D(2) DOPAMINE RECEPTOR PDB 8GU1 (CRYSTAL STRUCTURE OF PUTATIVE AMINO ACID BINDING PERIPLASMIC ABC TRANSPORTER PROTEIN FROM CANDIDATUS LIBERIBACTER ASIATICUS IN COMPLEX WITH PIMOZIDE) LIGAND CODE = 1II (link to the list of PDB complexes) Download experimental 3D coordinates of 1II with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 more at DrugCentral | EMA | |||
