Cheminformatic Tools and Databases for Pharmacology

session 84418 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PRAZOSIN

PRAZOSIN


ATC C02CA01
ATC C02LE01

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC ALPHA-ANTAGONISTS
ALPHA-ADRENERGIC BLOCKING AGENTS

ORAL

Tmax 3 HOUR

F 90 PERCENT

VD 47 LITER (65 KILOGRAM)

PPB 94 PERCENT

Cl 18.3 LITER / HOUR (65 KILOGRAM)

HT 2.5 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

ALPHA-1A ADRENERGIC RECEPTOR
ALPHA-1B ADRENERGIC RECEPTOR
ALPHA-1D ADRENERGIC RECEPTOR

PDB 3OWX (X-RAY STRUCTURAL STUDY OF QUINONE REDUCTASE II INHIBITION BY COMPOUNDS WITH MICROMOLAR TO NANOMOLAR RANGE IC50 VALUES)

LIGAND CODE = XRA (link to the list of PDB complexes)

Download experimental 3D coordinates of XRA with added hydrogens

ADRENERGIC RECEPTOR ALPHA-1 ANTAGONIST CHEMBL2094251 ADRENERGIC RECEPTOR ALPHA-1 P25100 ALPHA-1D ADRENERGIC RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ADRENERGIC RECEPTORANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |