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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLONIDINE

CLONIDINE


ATC C02AC01
ATC N02CX02
ATC S01EA04
ATC C02LC01
ATC C02LC51

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC ALPHA AGONISTS
ANTIMIGRAINE
SYMPATHOMIMETICS IN GLAUCOMA THERAPY
IMIDAZOLINE DERIVATIVE

ORAL TRANSDERMAL INJECTION

Cmax 19.1 NANOMOLAR

Tmax 4 HOUR

VD 136 LITER

PPB 40 PERCENT

Cl 13.1 LITER / HOUR

HT 14 HOUR

SOLUBILITY SOLUBLE IN WATER

ALPHA ADRENERGIC RECEPTOR

PDB 2PNC (CRYSTAL STRUCTURE OF BOVINE PLASMA COPPER-CONTAINING AMINE OXIDASE IN COMPLEX WITH CLONIDINE)

LIGAND CODE = CLU (link to the list of PDB complexes)

Download experimental 3D coordinates of CLU with added hydrogens

ADRENERGIC RECEPTOR ALPHA-2 AGONIST CHEMBL2095158 ADRENERGIC RECEPTOR ALPHA-2 P08913 ALPHA-2A ADRENERGIC RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ADRENERGIC RECEPTORANSM (in French)

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