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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLONIDINE
| CLONIDINE |
CARDIOVASCULAR | ORAL TRANSDERMAL INJECTION | Cmax 19.1 NANOMOLAR Tmax 4 HOUR VD 136 LITER PPB 40 PERCENT Cl 13.1 LITER / HOUR HT 14 HOUR SOLUBILITY SOLUBLE IN WATER | ALPHA ADRENERGIC RECEPTOR PDB 2PNC (CRYSTAL STRUCTURE OF BOVINE PLASMA COPPER-CONTAINING AMINE OXIDASE IN COMPLEX WITH CLONIDINE) LIGAND CODE = CLU (link to the list of PDB complexes) Download experimental 3D coordinates of CLU with added hydrogens | Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B more at DrugCentral | EMA | |||
