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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRIMETHOPRIM
| TRIMETHOPRIM |
ANTIINFECTIVES | ORAL INJECTION OPHTHALMIC | Cmax 3.44 MICROMOLAR Tmax 2.5 HOUR VD 97.5 LITER (65 KILOGRAM) PPB 44 PERCENT Cl 8.1 LITER / HOUR (65 KILOGRAM) HT 9 HOUR | DIHYDROFOLATE REDUCTASE PDB 3FRB (S. AUREUS F98Y DHFR COMPLEXED WITH TMP) LIGAND CODE = TOP (link to the list of PDB complexes) Download experimental 3D coordinates of TOP with added hydrogens | Dihydrofolate reductase UNIPROT P0ABQ4 folA more at DrugCentral | EMA | |||
