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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FLOXURIDINE (has an active metabolite)

FLOXURIDINE


ATC L01BC09

ANTINEOPLASTIC
ANTIMETABOLITES
INTERFERE WITH THE SYNTHESIS OF DNA AND RNA
RAPIDLY CATABOLIZED TO 5-FLUOROURACIL

INJECTION

SOLUBILITY FREELY SOLUBLE IN WATER

URIDINE 5-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE)

PDB 2QCF (CRYSTAL STRUCTURE OF THE OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASE DOMAIN (ASP312ASN MUTANT) OF HUMAN UMP SYNTHASE BOUND TO 5-FLUORO-UMP)

LIGAND CODE = 5FU (link to the list of PDB complexes)

Download experimental 3D coordinates of 5FU with added hydrogens

Thymidylate synthase UNIPROT P04818 TYMS

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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