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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRETINOIN
| TRETINOIN |
DERMATOLOGICALS | TOPICAL ORAL | Cmax 1.31 MICROMOLAR Tmax 1.5 HOUR PPB 95 PERCENT HT 1.25 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | RETINOIC ACID RECEPTOR (RAR) CRABP I CRABP II PDB 3CWK (CRYSTAL STRUCTURE OF THE R132K:Y134F:R111L:T54V:L121E MUTANT OF CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AT 1.57 ANGSTROMS RESOLUTION) LIGAND CODE = REA_3CWK (link to the list of PDB complexes) Download experimental 3D coordinates of REA_3CWK with added hydrogens | Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor beta UNIPROT P10826 RARB more at DrugCentral | EMA | |||
