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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MITOTANE

MITOTANE


ATC L01XX23

ANTINEOPLASTIC
ADRENAL CYTOTOXIC AGENT
TREATMENT OF INOPERABLE ADRENAL CORTICAL CARCINOMA
STEROID AND XENOBIOTIC RECEPTOR (SXR) AGONIST (PMID23179081)

ORAL

Cmax 44.7 MICROMOLAR

F 40 PERCENT

HT 2124 HOUR

SXR RECEPTOR

CYTOCHROME P450 11A1 INHIBITOR CHEMBL2033 CYTOCHROME P450 11A1 P05108 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_11 CYP_11A CYP_11A1ANSM (in French)

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