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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CYTARABINE (has an active metabolite)
| CYTARABINE | ANTINEOPLASTIC | INJECTION INTRAVENOUS | Cmax 205.7 MICROMOLAR Tmax 1 HOUR VD 0.89 LITER (EQN) Cl 0.014 LITER / HOUR HT 44.1 HOUR | CYTIDINE KINASE PDB 1P5Z (STRUCTURE OF HUMAN DCK COMPLEXED WITH CYTARABINE AND ADP-MG) LIGAND CODE = AR3 (link to the list of PDB complexes) Download experimental 3D coordinates of AR3 with added hydrogens | DNA polymerase (alpha,delta,epsilon) UNIPROT P09884 POLA1 more at DrugCentral | EMA | |||
