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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PROCARBAZINE

PROCARBAZINE


ATC L01XB01

ANTINEOPLASTIC
TREATMENT OF STAGE III AND IV HODGKIN'S DISEASE
MAY INHIBIT TRANSMETHYLATION OF METHYL GROUPS OF METHIONINE INTO T-RNA
HYDROGEN PEROXIDE FORMED DURING THE AUTO-OXIDATION OF THE DRUG MAY ATTACK PROTEIN SULFHYDRYL GROUPS CONTAINED IN RESIDUAL PROTEIN WHICH IS TIGHTLY BOUND TO DNA

 ORAL

Tmax 1 HOUR

F 100 PERCENT

HT 0.16 HOUR

SOLUBILITY SOLUBLE BUT UNSTABLE IN WATER

 DNA

 Unknown

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