CARBAMAZEPINE (has an active metabolite) | CARBAMAZEPINE | ATC N03AF01
NERVOUS SYSTEM ANTICONVULSANT ANALGESIC ANTIMANIC AGENTS SPECIFIC ANALGESIC FOR TRIGEMINAL NEURALGIA CARBAMAZEPINE INDUCES ITS OWN METABOLISM MECHANISM OF ACTION UNKNOWN (NUMEROUS PHARMACOLOGICAL EFFECTS HAVE BEEN DESCRIBED MODULATION OF ION CHANNELS (SODIUM AND CALCIUM), RECEPTOR-MEDIATED NEUROTRANSMISSION (GABAERGIC, GLUTAMATERGIC, AND MONOAMINERGIC), AND INTRACELLULAR SIGNALING PATHWAYS) | ORAL INTRAVENOUS | Cmax 8 MICROMOLAR Tmax 19 HOUR F 89 PERCENT VD 74.7 LITER (65 KILOGRAM) PPB 76 PERCENT Cl 4.8 LITER / HOUR HT 37.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | VOLTAGE-GATED SODIUM CHANNELS PDB 6TFB (CARBAMAZEPINE BINDS FRIZZLED8) LIGAND CODE = N6W (link to the list of PDB complexes) Download experimental 3D coordinates of N6W with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |
M CARBAMAZEPINE (is an active metabolite) | CARBAMAZEPINE | ATC N03AF01
NERVOUS SYSTEM ANTICONVULSANT ANALGESIC ANTIMANIC AGENTS SPECIFIC ANALGESIC FOR TRIGEMINAL NEURALGIA CARBAMAZEPINE INDUCES ITS OWN METABOLISM MECHANISM OF ACTION UNKNOWN (NUMEROUS PHARMACOLOGICAL EFFECTS HAVE BEEN DESCRIBED MODULATION OF ION CHANNELS (SODIUM AND CALCIUM), RECEPTOR-MEDIATED NEUROTRANSMISSION (GABAERGIC, GLUTAMATERGIC, AND MONOAMINERGIC), AND INTRACELLULAR SIGNALING PATHWAYS) | - | Cmax 8.7 MICROMOLAR Tmax 14 HOUR PPB 50 PERCENT HT 34 HOUR | VOLTAGE-GATED SODIUM CHANNELS | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |