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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACETAMINOPHEN
| ACETAMINOPHEN | NATURAL MOLECULE (link)
NERVOUS SYSTEM | RECTAL ORAL INJECTION INTRAVENOUS | Cmax 27.8 NANOMOLAR Tmax 1 HOUR VD 58.5 LITER (65 KILOGRAM) PPB 20 PERCENT Cl 17.5 LITER / HOUR (65 KILOGRAM) HT 2.1 HOUR | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 2DPZ (STRUCTURE OF THE COMPLEX OF PHOSPHOLIPASE A2 WITH N-(4-HYDROXYPHENYL)- ACETAMIDE AT 2.1 A RESOLUTION) LIGAND CODE = TYL (link to the list of PDB complexes) Download experimental 3D coordinates of TYL with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Transient receptor potential cation channel subfamily V member 1 UNIPROT Q8NER1 TRPV1 more at DrugCentral | EMA | |||
