Cheminformatic Tools and Databases for Pharmacology

session 54627 - Total of 1 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROXYUREA

HYDROXYUREA


ATC L01XX05

ANTINEOPLASTIC
ANTISICKLING AGENTS (SICKLE CELL DISEASE)
NUCLEIC ACID SYNTHESIS INHIBITORS
INHIBITION OF DNA SYNTHESIS BY ACTING AS A RIBONUCLEOTIDE REDUCTASE INHIBITOR

ORAL

Tmax 2.5 HOUR

VD 40 LITER

PPB 0 PERCENT

Cl 5.8 LITER / HOUR (65 KILOGRAM)

HT 3.4 HOUR

RIBONUCLEOSIDE REDUCTASE

PDB 3UB9 (PERIPLASMIC PORTION OF THE HELICOBACTER PYLORI CHEMORECEPTOR TLPB WITH HYDROXYUREA BOUND)

LIGAND CODE = NHY (link to the list of PDB complexes)

Download experimental 3D coordinates of NHY with added hydrogens

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE RR1 INHIBITOR CHEMBL2095215 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE RR1 P31350 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 HOMO SAPIENS ENZYMEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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