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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDROXYUREA
| HYDROXYUREA | ANTINEOPLASTIC | ORAL | Tmax 2.5 HOUR VD 40 LITER PPB 0 PERCENT Cl 5.8 LITER / HOUR (65 KILOGRAM) HT 3.4 HOUR | RIBONUCLEOSIDE REDUCTASE PDB 3UB9 (PERIPLASMIC PORTION OF THE HELICOBACTER PYLORI CHEMORECEPTOR TLPB WITH HYDROXYUREA BOUND) LIGAND CODE = NHY (link to the list of PDB complexes) Download experimental 3D coordinates of NHY with added hydrogens | Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1 -- Ribonucleoside-diphosphate reductase subunit M2 UNIPROT P31350 RRM2 more at DrugCentral | EMA | |||
