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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FUROSEMIDE
| FUROSEMIDE |
CARDIOVASCULAR | ORAL INJECTION SUBCUTANEOUS | Tmax 1.5 HOUR F 60 PERCENT VD 7.8 LITER (65 KILOGRAM) PPB 95 PERCENT Cl 6.2 LITER / HOUR (65 KILOGRAM) HT 2 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | NKCC1 CFTR PDB 3RF4 (ANCYLOSTOMA CEYLANICUM MIF IN COMPLEX WITH FUROSEMIDE) LIGAND CODE = FUN (link to the list of PDB complexes) Download experimental 3D coordinates of FUN with added hydrogens | Solute carrier family 12 member 1 UNIPROT Q13621 SLC12A1 more at DrugCentral | EMA | |||
