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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PENTAZOCINE
| PENTAZOCINE | NERVOUS SYSTEM | INJECTION ORAL | Tmax 1.7 HOUR VD 221 LITER (65 KILOGRAM) PPB 61 PERCENT Cl 89.7 LITER / HOUR (65 KILOGRAM) HT 3.6 HOUR SOLUBILITY SOLUBLE IN ACIDIC AQUEOUS SOLUTION | SIGMA OPIOID RECEPTOR PDB 6DK1 (HUMAN SIGMA-1 RECEPTOR BOUND TO (+)-PENTAZOCINE) LIGAND CODE = GM4 (link to the list of PDB complexes) Download experimental 3D coordinates of GM4 with added hydrogens | Sigma non-opioid intracellular receptor 1 UNIPROT Q99720 SIGMAR1 more at DrugCentral | EMA | |||
