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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIHYDROERGOTAMINE

DIHYDROERGOTAMINE


ATC N02CA01
ATC N02CA51

NERVOUS SYSTEM
VASOCONSTRICTOR
ANTIMIGRAINE
ANALGESICS NON-NARCOTIC
5-HYDROXYTRYPTAMINE 1 RECEPTOR AGONISTS
SYMPATHOLYTICS

INJECTION NASAL

Cmax 7.6 NANOMOLAR (PMID8841149)

Tmax 0.38 HOUR

VD 800 LITER

PPB 93 PERCENT

Cl 90 LITER / HOUR

HT 9 HOUR

5-HYDROXYTRYPTAMINE 1 RECEPTOR
5-HYDROXYTRYPTAMINE 2 RECEPTOR
ALPHA ADRENERGIC RECEPTOR
DOPAMINE RECEPTOR

PDB 4IAQ (CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET))

LIGAND CODE = 2GM (link to the list of PDB complexes)

Download experimental 3D coordinates of 2GM with added hydrogens

SEROTONIN 1D (5-HT1D) RECEPTOR AGONIST CHEMBL1983 SEROTONIN 1D (5-HT1D) RECEPTOR P28221 5-HYDROXYTRYPTAMINE RECEPTOR 1D HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR SEROTONIN RECEPTORANSM (in French)

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