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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ALLOPURINOL (has an active metabolite)

ALLOPURINOL


ATC M04AA01
ATC M04AA51

MUSCULO-SKELETAL SYSTEM
TREATMENT OF HYPERURICEMIA (GOUT SUPPRESSANT)
XANTHINE OXIDASE INHIBITOR
ANTIMETABOLITES
ACTS ON PURINE CATABOLISM AND REDUCES THE PRODUCTION OF URIC ACID

ORAL INJECTION

Cmax 22 MICROMOLAR

Tmax 1.5 HOUR

F 90 PERCENT

VD 37.7 LITER (65 KILOGRAM)

PPB 3 PERCENT

Cl 42.9 LITER / HOUR (65 KILOGRAM)

HT 1.5 HOUR

SOLUBILITY 8 MILLIGRAM / LITER IN WATER

XANTHINE OXIDASE

Xanthine dehydrogenase,oxidase UNIPROT P47989 XDH

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M ALLOPURINOL (is an active metabolite)

ALLOPURINOL


ATC M04AA01
ATC M04AA51

MUSCULO-SKELETAL SYSTEM
TREATMENT OF HYPERURICEMIA (GOUT SUPPRESSANT)
XANTHINE OXIDASE INHIBITOR
ANTIMETABOLITES
ACTS ON PURINE CATABOLISM AND REDUCES THE PRODUCTION OF URIC ACID

-

Cmax 42.7 MICROMOLAR

Tmax 4.5 HOUR

HT 15 HOUR

XANTHINE OXIDASE

Xanthine dehydrogenase,oxidase UNIPROT P47989 XDH

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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