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session 24208 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ALLOPURINOL (has an active metabolite)

ALLOPURINOL


ATC M04AA01
ATC M04AA51

MUSCULO-SKELETAL SYSTEM
TREATMENT OF HYPERURICEMIA (GOUT SUPPRESSANT)
XANTHINE OXIDASE INHIBITOR
ANTIMETABOLITES
ACTS ON PURINE CATABOLISM AND REDUCES THE PRODUCTION OF URIC ACID

ORAL INJECTION

Cmax 22 MICROMOLAR

Tmax 1.5 HOUR

F 90 PERCENT

VD 37.7 LITER (65 KILOGRAM)

PPB 3 PERCENT

Cl 42.9 LITER / HOUR (65 KILOGRAM)

HT 1.5 HOUR

SOLUBILITY 8 MILLIGRAM / LITER IN WATER

XANTHINE OXIDASE

XANTHINE DEHYDROGENASE INHIBITOR CHEMBL1929 XANTHINE DEHYDROGENASE P47989 XANTHINE DEHYDROGENASE/OXIDASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M ALLOPURINOL (is an active metabolite)

ALLOPURINOL


ATC M04AA01
ATC M04AA51

MUSCULO-SKELETAL SYSTEM
TREATMENT OF HYPERURICEMIA (GOUT SUPPRESSANT)
XANTHINE OXIDASE INHIBITOR
ANTIMETABOLITES
ACTS ON PURINE CATABOLISM AND REDUCES THE PRODUCTION OF URIC ACID

-

Cmax 42.7 MICROMOLAR

Tmax 4.5 HOUR

HT 15 HOUR

XANTHINE OXIDASE

XANTHINE DEHYDROGENASE INHIBITOR CHEMBL1929 XANTHINE DEHYDROGENASE P47989 XANTHINE DEHYDROGENASE/OXIDASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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