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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FENTANYL
| FENTANYL |
NERVOUS SYSTEM | INJECTION TRANSDERMAL ORAL TRANSMUCOSAL IONTOPHORESIS BUCCAL SUBLINGUAL NASAL INTRAVENOUS | Cmax 7.4 NANOMOLAR Tmax 0.33 HOUR F 50 PERCENT VD 260 LITER (65 KILOGRAM) PPB 82 PERCENT Cl 32.5 LITER / HOUR (65 KILOGRAM) HT 7 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | MU-TYPE OPIOID RECEPTOR PDB 5TZO (COMPUTATIONALLY DESIGNED FENTANYL BINDER - FEN49*-COMPLEX) LIGAND CODE = 7V7 (link to the list of PDB complexes) Download experimental 3D coordinates of 7V7 with added hydrogens | Mu-type opioid receptor UNIPROT P35372 OPRM1 more at DrugCentral | EMA | |||
