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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMANTADINE

AMANTADINE


ATC N04BB01

NERVOUS SYSTEM
ANTIVIRAL
ANTIPARKINSONIAN
TREATMENT OF DRUG-INDUCED EXTRAPYRIMIDAL REACTIONS

ORAL

Cmax 1.45 MICROMOLAR

Tmax 3.3 HOUR

VD 357 LITER (65 KILOGRAM)

PPB 67 PERCENT

Cl 18.2 LITER / HOUR (65 KILOGRAM)

HT 17 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

(PUTATIVE) NICOTINIC ACETYLCHOLINE RECEPTOR

PDB 2KQT (SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE)

LIGAND CODE = 308 (link to the list of PDB complexes)

Download experimental 3D coordinates of 308 with added hydrogens

GLUTAMATE [NMDA] RECEPTOR ANTAGONIST CHEMBL2094124 GLUTAMATE [NMDA] RECEPTOR O15399 GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D HOMO SAPIENS ION CHANNEL LGIC GLUT NMDAANSM (in French)

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