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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMINOCAPROIC ACID

AMINOCAPROIC ACID


ATC B02AA01

BLOOD
HEMOSTATIC
ANTIFIBRINOLYTIC AGENTS
COMPETITIVE INHIBITOR OF PLASMIN

ORAL INJECTION

Cmax 1.25 MILLIMOLAR

Tmax 1.2 HOUR

F 100 PERCENT

VD 23.1 LITER

PPB 8 PERCENT

Cl 10.1 LITER / HOUR

HT 2 HOUR

SOLUBILITY SOLUBLE IN WATER

PLASMINOGEN

PDB 2ZM9 (STRUCTURE OF 6-AMINOHEXANOATE-DIMER HYDROLASE, A61V/S112A/A124V/R187S/F264C/G291R/G338A/D370Y MUTANT (HYB-S4M94) WITH SUBSTRATE)

LIGAND CODE = ACA (link to the list of PDB complexes)

Download experimental 3D coordinates of ACA with added hydrogens

PLASMINOGEN INHIBITOR CHEMBL1801 PLASMINOGEN P00747 PLASMINOGEN HOMO SAPIENS ENZYME PROTEASE SERINE PAS S1AANSM (in French)

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