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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VINCRISTINE

VINCRISTINE


ATC L01CA02

ANTINEOPLASTIC
ALKALOID FROM A COMMON FLOWERING HERB THE PERIWINKLE PLANT (VINCA ROSEA LINN)
TUBULIN MODULATORS
TREATMENT OF ACUTE LEUKEMIA
INHIBITION OF MICROTUBULE FORMATION IN MITOTIC SPINDLE, RESULTING IN AN ARREST OF DIVIDING CELLS AT THE METAPHASE STAGE

INJECTION INTRAVENOUS

VD 156 LITER (65 KILOGRAM)

PPB 60 PERCENT

Cl 7.8 LITER / HOUR (65 KILOGRAM)

HT 87 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

TUBULIN BETA CHAIN

PDB 7A69 (NANODISC RECONSTITUTED HUMAN ABCB1 IN COMPLEX WITH MRK16 FAB AND VINCRISTINE)

LIGAND CODE = R1Q (link to the list of PDB complexes)

Download experimental 3D coordinates of R1Q with added hydrogens

TUBULIN INHIBITOR CHEMBL2095182 TUBULIN P04350 TUBULIN BETA-4A CHAIN HOMO SAPIENS STRUCTURALANSM (in French)

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