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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACETOHEXAMIDE DISCONTINUED (has an active metabolite)
| ACETOHEXAMIDE | METABOLISM | ORAL | ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL PDB 8J2O (CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN-COMPLEX WITH ACETOHEXAMIDE AT 2.6 A RESOLUTION) LIGAND CODE = TF9 (link to the list of PDB complexes) Download experimental 3D coordinates of TF9 with added hydrogens | Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8 more at DrugCentral | EMA | ||||
