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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIPYRIDAMOLE

DIPYRIDAMOLENATURAL MOLECULE (link)


ATC B01AC07

BLOOD
CORONARY VASODILATOR
PHOSPHODIESTERASE INHIBITORS
ANTIPLATELET AGENT
INHIBITS THE UPTAKE OF ADENOSINE INTO PLATELETS

ORAL INJECTION

Cmax 3.92 MICROMOLAR

Tmax 2 HOUR

VD 92 LITER

PPB 99 PERCENT

Cl 4.6 LITER / HOUR (EQN)

HT 13.6 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (LOGP=3.71)

PHOSPHODIESTERASE

PDB 8I4A (CRYO-EM STRUCTURE OF DIPYRIDAMOLE-BOUND ABCC4)

LIGAND CODE = H9F (link to the list of PDB complexes)

Download experimental 3D coordinates of H9F with added hydrogens

cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A -- cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A UNIPROT Q9Y233 PDE10A

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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