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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SULFAMETHOXAZOLE
| SULFAMETHOXAZOLE | ANTIINFECTIVES | ORAL INJECTION | Cmax 268.7 MICROMOLAR Tmax 2.5 HOUR VD 19.5 LITER (65 KILOGRAM) PPB 70 PERCENT Cl 1.4 LITER / HOUR (65 KILOGRAM) HT 10 HOUR | DIHYDROPTEROATE SYNTHASE (DHPS) PDB 3TZF (CRYSTAL STRUCTURE OF THE YERSINIA PESTIS DIHYDROPTEROATE SYNTHASE WITH SULFONAMIDE DRUG COMPLEX.) LIGAND CODE = 08D (link to the list of PDB complexes) Download experimental 3D coordinates of 08D with added hydrogens | Dihydropteroate synthase UNIPROT P0AC13 folP more at DrugCentral | EMA | |||
