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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMITRIPTYLINE
| AMITRIPTYLINE | NERVOUS SYSTEM | ORAL INJECTION | VD 565.5 LITER (65 KILOGRAM) PPB 93 PERCENT Cl 23.7 LITER / HOUR (65 KILOGRAM) HT 17 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | NORADRENALINE TRANSPORTER PDB 3APV (CRYSTAL STRUCTURE OF THE A VARIANT OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND AMITRIPTYLINE COMPLEX) LIGAND CODE = TP0 (link to the list of PDB complexes) Download experimental 3D coordinates of TP0 with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
