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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIPHENHYDRAMINE

DIPHENHYDRAMINE
DIMENHYDRINATE


ATC D04AA32
ATC R06AA02
ATC D04AA33
ATC R06AA52

RESPIRATORY
ANESTHETICS
ANTI-ALLERGIC AGENTS
ANTIDYSKINETICS
ANTIHISTAMINE
ANTIEMETICS
ANTIPARKINSON AGENTS
ANTIPRURITICS
ANTITUSSIVES
ETHANOLAMINE DERIVATIVES
HISTAMINE H1 ANTAGONISTS
HYPNOTICS AND SEDATIVES
DIMENHYDRINATE IS A COMBINATION WITH CHLORO-THEOPHYLLINE

ORAL INJECTION

Cmax 207.8 NANOMOLAR (PMID3718600)

Tmax 2.5 HOUR

VD 422 LITER (65 KILOGRAM)

PPB 81 PERCENT

Cl 38.2 LITER / HOUR (65 KILOGRAM)

HT 9.3 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

HISTAMINE H1 RECEPTOR

PDB 2AOT (HISTAMINE METHYLTRANSFERASE COMPLEXED WITH THE ANTIHISTAMINE DRUG DIPHENHYDRAMINE)

LIGAND CODE = 2PM (link to the list of PDB complexes)

Download experimental 3D coordinates of 2PM with added hydrogens

HISTAMINE H1 RECEPTOR ANTAGONIST CHEMBL231 HISTAMINE H1 RECEPTOR P35367 HISTAMINE H1 RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR HISTAMINE RECEPTORANSM (in French)

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