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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIPHENHYDRAMINE
| DIPHENHYDRAMINE DIMENHYDRINATE |
RESPIRATORY | ORAL INJECTION | Cmax 207.8 NANOMOLAR (PMID3718600) Tmax 2.5 HOUR VD 422 LITER (65 KILOGRAM) PPB 81 PERCENT Cl 38.2 LITER / HOUR (65 KILOGRAM) HT 9.3 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | HISTAMINE H1 RECEPTOR PDB 2AOT (HISTAMINE METHYLTRANSFERASE COMPLEXED WITH THE ANTIHISTAMINE DRUG DIPHENHYDRAMINE) LIGAND CODE = 2PM (link to the list of PDB complexes) Download experimental 3D coordinates of 2PM with added hydrogens | Histamine H1 receptor UNIPROT P35367 HRH1 more at DrugCentral | EMA | |||
