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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ATROPINE

ATROPINENATURAL MOLECULE (link)


ATC A03BA01
ATC S01FA01
ATC A03CB03

METABOLISM
ALKALOID
ANTICHOLINERGIC
MUSCARINIC ANTAGONISTS
MYDRIATICS
PARASYMPATHOLYTICS
ACTIVITY IS DUE ALMOST ENTIRELY TO THE LEVO ISOMER
TREATMENT OF POISONING BY ORGANOPHOSPHOROUS NERVE AGENTS

ORAL INTRAMUSCULAR INJECTION INHALATION INTRAVENOUS OPHTHALMIC SUBCUTANEOUS INTRAOSSEOUS ENDOTRACHEAL

Cmax 33.2 NANOMOLAR

Tmax 0.05 HOUR

VD 214.5 LITER (65 KILOGRAM)

PPB 18 PERCENT

Cl 29.6 LITER / HOUR (65 KILOGRAM)

HT 3 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

MUSCARINIC ACETYLCHOLINE RECEPTOR

PDB 1TH6 (RUSSELLS VIPER PHOSPHOLIPASE A2)

MUSCARINIC ACETYLCHOLINE RECEPTOR M2 ANTAGONIST CHEMBL211 MUSCARINIC ACETYLCHOLINE RECEPTOR M2 P08172 MUSCARINIC ACETYLCHOLINE RECEPTOR M2 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR ACETYLCHOLINE RECEPTORANSM (in French)

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