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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRANYLCYPROMINE

TRANYLCYPROMINE


ATC N06AF04

NERVOUS SYSTEM
ANTIDEPRESSANT
ANTI-ANXIETY AGENTS
MONOAMINE OXIDASE (MAO) INHIBITORS

ORAL

Cmax 368.4 NANOMOLAR (PMID12959316)

Tmax 1 HOUR (PMID3757407)

VD 144.5 LITER (EQN)

Cl 63.4 LITER / HOUR

HT 1.58 HOUR

MONOAMINE OXIDASE MAO

PDB 3MDR (TRANYLCYPROMINE COMPLEX OF CYTOCHROME P450 46A1)

LIGAND CODE = GJZ (link to the list of PDB complexes)

Download experimental 3D coordinates of GJZ with added hydrogens

MONOAMINE OXIDASE INHIBITOR CHEMBL2095205 MONOAMINE OXIDASE P21397 AMINE OXIDASE [FLAVIN-CONTAINING] A HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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