FLUOROURACIL (is an active metabolite) (has an active metabolite) | FLUOROURACIL | ATC L01BC02 ATC L01BC52
ANTINEOPLASTIC ANTIMETABOLITES IMMUNOSUPPRESSIVE AGENTS | INJECTION TOPICAL | Cmax 88.3 NANOMOLAR Tmax 1.03 HOUR VD 14.9 LITER (65 KILOGRAM) PPB 85 PERCENT Cl 101.4 LITER / HOUR (65 KILOGRAM) HT 0.12 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | THYMIDYLATE SYNTHASE PDB 3KVR (TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS) LIGAND CODE = URF (link to the list of PDB complexes) Download experimental 3D coordinates of URF with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |