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session 68984 - Total of 3 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ISOSORBIDE DISCONTINUED (is an active metabolite)	ISOSORBIDE	ATC C01DA08 ATC C05AE02 ATC C01DA58 ATC C01DA14 CARDIOVASCULAR VASODILATOR FROM THE RELEASE OF NITRIC OXIDE OSMOTIC AGENT TO PROMOTE REDISTRIBUTION OF WATER TOWARD THE CIRCULATION WITH ULTIMATE ELIMINATION IN THE URINE	ORAL			Unknown more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ISOSORBIDE DINITRATE (has an active metabolite)	ISOSORBIDE DINITRATE	ATC C01DA08 ATC C05AE02 ATC C01DA58 CARDIOVASCULAR VASODILATOR FROM THE RELEASE OF NITRIC OXIDE AND THE SUBSEQUENT ACTIVATION OF GUANYLYL CYCLASE AND ULTIMATE RELAXATION OF VASCULAR SMOOTH MUSCLE ANTIANGINAL	ORAL SUBLINGUAL	Cmax 0.32 MICROMOLAR (40 MILLIGRAM) F 25 PERCENT VD 195 LITER PPB 28 PERCENT Cl 180 LITER / HOUR HT 1 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER		Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
ISOSORBIDE MONONITRATE (is an active metabolite) (has an active metabolite)	ISOSORBIDE MONONITRATE	ATC C01DA14 CARDIOVASCULAR VASODILATOR FROM THE RELEASE OF NITRIC OXIDE	ORAL	Cmax 6.5 MICROMOLAR (60 MILLIGRAM) F 100 PERCENT VD 42.2 LITER PPB 0 PERCENT Cl 7 LITER / HOUR HT 5 HOUR SOLUBILITY FREELY SOLUBLE IN WATER		Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank