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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ISOSORBIDE DINITRATE

ISOSORBIDE DINITRATE


ATC C01DA08
ATC C05AE02
ATC C01DA58

CARDIOVASCULAR
VASODILATOR FROM THE RELEASE OF NITRIC OXIDE AND THE SUBSEQUENT ACTIVATION OF GUANYLYL CYCLASE AND ULTIMATE RELAXATION OF VASCULAR SMOOTH MUSCLE
ANTIANGINAL

ORAL SUBLINGUAL

Cmax 0.32 MICROMOLAR (40 MILLIGRAM)

F 25 PERCENT

VD 195 LITER

PPB 28 PERCENT

Cl 180 LITER / HOUR

HT 1 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

SOLUBLE GUANYLATE CYCLASE ACTIVATOR CHEMBL2111348 SOLUBLE GUANYLATE CYCLASE O75343 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 HOMO SAPIENS ENZYME LYASE GUANYLATE CYCLASE SOLUBLE GUANYLATE CYCLASEANSM (in French)

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