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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ISOSORBIDE DINITRATE (has an active metabolite)
| ISOSORBIDE DINITRATE |
CARDIOVASCULAR | ORAL SUBLINGUAL | Cmax 0.32 MICROMOLAR (40 MILLIGRAM) F 25 PERCENT VD 195 LITER PPB 28 PERCENT Cl 180 LITER / HOUR HT 1 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | Soluble guanylate cyclase UNIPROT O75343 GUCY1B2 more at DrugCentral | EMA | ||||
