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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDROFLUMETHIAZIDE DISCONTINUED
| HYDROFLUMETHIAZIDE |
CARDIOVASCULAR | ORAL | VD 143 LITER (65 KILOGRAM) Cl 37.8 LITER / HOUR (65 KILOGRAM) HT 5.2 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | CARBONIC ANHYDRASE PDB 3ILU (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROFLUMETHIAZIDE) LIGAND CODE = HFZ (link to the list of PDB complexes) Download experimental 3D coordinates of HFZ with added hydrogens | Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 more at DrugCentral | EMA | |||
