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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROFLUMETHIAZIDE DISCONTINUED

HYDROFLUMETHIAZIDE


ATC C03AA02
ATC C03AB02
ATC C03AH02

CARDIOVASCULAR
DIURETIC
ANTIHYPERTENSIVE
CARBONIC ANHYDRASE INHIBITORS (PMID23488823)
ADJUNCTIVE THERAPY IN EDEMA

ORAL

VD 143 LITER (65 KILOGRAM)

Cl 37.8 LITER / HOUR (65 KILOGRAM)

HT 5.2 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

CARBONIC ANHYDRASE

PDB 3ILU (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROFLUMETHIAZIDE)

LIGAND CODE = HFZ (link to the list of PDB complexes)

Download experimental 3D coordinates of HFZ with added hydrogens

THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER INHIBITOR CHEMBL1876 THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER P55017 SOLUTE CARRIER FAMILY 12 MEMBER 3 HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC12ANSM (in French)

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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
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