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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DEXAMETHASONE (is an active metabolite)

DEXAMETHASONE


ATC A01AC02
ATC C05AA09
ATC D07AB19
ATC D07XB05
ATC D10AA03
ATC H02AB02
ATC R01AD03
ATC S01BA01
ATC S01CB01
ATC S02BA06
ATC S03BA01
ATC D07CB04
ATC S01CA01
ATC S02CA06
ATC S03CA01
ATC R01AD53

DERMATOLOGICALS
GLUCOCORTICOID
ANTI-INFLAMMATORY AGENTS

ORAL TOPICAL OPHTHALMIC OTIC INTRAVITREAL INTRAOCULAR

VD 61.1 LITER (65 KILOGRAM)

PPB 68 PERCENT

Cl 12.8 LITER / HOUR (65 KILOGRAM)

HT 3.7 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

GLUCOCORTICOID RECEPTOR

PDB 4UDC (GR IN COMPLEX WITH DEXAMETHASONE)

LIGAND CODE = DEX (link to the list of PDB complexes)

Download experimental 3D coordinates of DEX with added hydrogens

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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