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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMPHETAMINE (is an active metabolite) (has an active metabolite)
| AMPHETAMINE | NERVOUS SYSTEM | ORAL | Cmax 185 NANOMOLAR VD 396 LITER (65 KILOGRAM) PPB 20 PERCENT Cl 37 LITER / HOUR (65 KILOGRAM) HT 7.3 HOUR | NORADRENALINE TRANSPORTER (NAT) DOPAMINE TRANSPORTER (DAT) PDB 2AOI (CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P1-P6) LIGAND CODE = FRD (link to the list of PDB complexes) Download experimental 3D coordinates of FRD with added hydrogens | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 -- Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHAMPHETAMINE (is an active metabolite) (has an active metabolite)
| METHAMPHETAMINE | NATURAL MOLECULE (link) NERVOUS SYSTEM | ORAL | F 67.2 PERCENT (PMID8104133) VD 242 LITER (65 KILOGRAM) PPB 15 PERCENT Cl 17.1 LITER / HOUR (65 KILOGRAM) HT 12.2 HOUR | DOPAMINE TRANSPORTER (DAT) SEROTONINE TRANSPORTER PDB 4XP6 (X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO PSYCHOSTIMULANT METHAMPHETAMINE) LIGAND CODE = B40 (link to the list of PDB complexes) Download experimental 3D coordinates of B40 with added hydrogens | Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
