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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRIAMCINOLONE ACETONIDE

TRIAMCINOLONE ACETONIDE

ANTIINFLAMMATORY
GLUCOCORTICOID
ANTIPRURITIC
VASOCONSTRICTIVE

TOPICAL INJECTION DENTAL INHALATION NASAL INTRAVITREAL

Cmax 2.58 NANOMOLAR

Tmax 0.5 HOUR

VD 99.5 LITER

PPB 68 PERCENT

Cl 45.2 LITER / HOUR

HT 1.46 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

GLUCOCORTICOID RECEPTOR

PDB 5UFS (X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH TRIAMCINOLONE ACETONIDE AND SHP COREGULATOR FRAGMENT)

LIGAND CODE = 1TA (link to the list of PDB complexes)

Download experimental 3D coordinates of 1TA with added hydrogens

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

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