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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| REPOTRECTINIB
| REPOTRECTINIB | ANTINEOPLASTIC | ORAL | Cmax 2 MICROMOLAR Tmax 2.5 HOUR F 45.7 PERCENT VD 432 LITER PPB 95.4 PERCENT Cl 15.9 LITER / HOUR HT 50.6 HOUR | TYROSINE-PROTEIN KINASE ROS1 PDB 7VKN (CRYSTAL STRUCTURE OF TRKA (G595R) KINASE WITH REPOTRECTINIB) LIGAND CODE = 7GI (link to the list of PDB complexes) Download experimental 3D coordinates of 7GI with added hydrogens | - more at DrugCentral | EMA | |||
