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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CAPIVASERTIB
| CAPIVASERTIB | ANTINEOPLASTIC | ORAL | Cmax 3.2 MICROMOLAR Tmax 1.5 HOUR F 29 PERCENT VD 1847 LITER PPB 22 PERCENT Cl 50 LITER / HOUR HT 8.3 HOUR SOLUBILITY PRACTICALLY INSOLUBLE AT PH VALUES ABOVE 6.8 | SERINE THREONINE KINASE AKT1 AKT2 AND AKT3 PDB 4GV1 (PKB ALPHA IN COMPLEX WITH AZD5363) LIGAND CODE = 0XZ (link to the list of PDB complexes) Download experimental 3D coordinates of 0XZ with added hydrogens | - more at DrugCentral | EMA | |||
