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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NIROGACESTAT
| NIROGACESTAT | ANTINEOPLASTIC | ORAL | Cmax 1.03 MICROMOLAR Tmax 1.5 HOUR F 19 PERCENT VD 1430 LITER PPB 99.6 PERCENT Cl 45 LITER / HOUR HT 23 HOUR SOLUBILITY SIGNIFICANTLY DECREASES AT PH HIGHER THAN 6.0 | GAMMA SECRETASE PDB 8KCT (CRYO-EM STRUCTURE OF HUMAN GAMMA-SECRETASE IN COMPLEX WITH NIROGACESTAT) LIGAND CODE = O6U (link to the list of PDB complexes) Download experimental 3D coordinates of O6U with added hydrogens | - more at DrugCentral | EMA | |||
