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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LOTILANER

LOTILANER

ANTIPARASITIC
TREATMENT OF DEMODEX BLEPHARITIS
GAMMA-AMINOBUTYRIC ACID (GABA)-GATED CHLORIDE CHANNEL INHIBITOR SELECTIVE FOR MITES (NOT AN INHIBITOR OF MAMMALIAN GABA)

OPHTHALMIC

Cmax 29.8 NANOMOLAR

Tmax 2 HOUR

PPB 99.9 PERCENT

HT 264 HOUR

GAMMA-AMINOBUTYRIC ACID (GABA)-GATED CHLORIDE CHANNEL

Gaba-gated chloride channel, putative UNIPROT E0V9W2 8233868

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