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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M MOMELOTINIB (is an active metabolite)
| MOMELOTINIB | ANTINEOPLASTIC | - | HT 6 HOUR | JANUS KINASE 1 AND 2 (JAK1/JAK2) | - more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MOMELOTINIB (has an active metabolite)
| MOMELOTINIB | ANTINEOPLASTIC | ORAL | Cmax 1.15 MICROMOLAR Tmax 2 HOUR VD 984 LITER PPB 91 PERCENT Cl 103 LITER / HOUR HT 6 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | JANUS KINASE 1 AND 2 (JAK1/JAK2) PDB 8BXH (CRYSTAL STRUCTURE OF JAK2 JH1 IN COMPLEX WITH MOMELOTINIB) LIGAND CODE = C87 (link to the list of PDB complexes) Download experimental 3D coordinates of C87 with added hydrogens | - more at DrugCentral | EMA | |||
