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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PALOVAROTENE

PALOVAROTENE


ATC PALOVAROTENE

MUSCULO-SKELETAL SYSTEM
RETINOID
REDUCTION IN THE VOLUME OF NEW HETEROTOPIC OSSIFICATION
TREATMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA (FOP)
RAR AGONIST

ORAL

Cmax 398 NANOMOLAR

Tmax 3.5 HOUR

VD 237 LITER

PPB 98 PERCENT

Cl 19.9 LITER / HOUR

HT 8.7 HOUR

RETINOIC ACID RECEPTOR GAMMA (RAR GAMMA)

Retinoic acid receptor gamma UNIPROT P13631

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
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