| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ELACESTRANT
| ELACESTRANT | GENITO | ORAL | Cmax 259.5 NANOMOLAR Tmax 2.5 HOUR F 10 PERCENT VD 5800 LITER PPB 99 PERCENT Cl 186 LITER / HOUR HT 40 HOUR SOLUBILITY FREELY SOLUBLE IN 0.01N HCL | ESTROGEN RECEPTOR ALPHA PDB 7TE7 (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH RAD1901) LIGAND CODE = I0V (link to the list of PDB complexes) Download experimental 3D coordinates of I0V with added hydrogens | Estrogen Receptor Alpha ESR1 UNIPROT P03372 more at DrugCentral | EMA | |||
