| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NIRMATRELVIR
| NIRMATRELVIR | ANTIINFECTIVES | ORAL | Cmax 6.8 MICROMOLAR Tmax 3 HOUR VD 104.7 LITER PPB 69 PERCENT Cl 8.99 LITER / HOUR HT 6.05 HOUR | SARS-COV-2 MAIN PROTEASE MPRO PDB 7SI9 (ROOM TEMPERATURE X-RAY STRUCTURE OF SARS-COV-2 MAIN PROTEASE (MPRO) IN COMPLEX WITH PF-07321332) LIGAND CODE = 4WI (link to the list of PDB complexes) Download experimental 3D coordinates of 4WI with added hydrogens | Replicase polyprotein 1ab rep UNIPROT P0DTD1 more at DrugCentral | EMA | |||
