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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DAPRODUSTAT DISCONTINUED

DAPRODUSTAT


ATC B03XA07

BLOOD
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH) INHIBITOR
PROLYL 4- HYDROXYLASES (PH)1, PH2 AND PH3 INHIBITOR
TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE

ORAL

Tmax 2.5 HOUR

F 65 PERCENT

VD 14.3 LITER

PPB 99 PERCENT

Cl 15 LITER / HOUR

HT 2.5 HOUR

SOLUBILITY POORLY SOLUBLE IN WATER

HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE HIF-PH1
HIF-PH2
HIF-PH3

Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1 -- Egl nine homolog 2 UNIPROT Q96KS0 EGLN2

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