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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SOTAGLIFLOZIN

SOTAGLIFLOZIN


ATC A10BK06

METABOLISM
SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITOR
SODIUM-GLUCOSE COTRANSPORTER 1 (SGLT1) INHIBITOR

ORAL

Tmax 2.1 HOUR

F 25 PERCENT

VD 9000 LITER

PPB 93 PERCENT

Cl 315 LITER / HOUR

HT 28 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2)
SODIUM-GLUCOSE COTRANSPORTER 1 (SGLT1)

PDB 8HG7 (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH SOTAGLIFLOZIN)

LIGAND CODE = LFL (link to the list of PDB complexes)

Download experimental 3D coordinates of LFL with added hydrogens

Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 -- Sodium,glucose cotransporter 1 UNIPROT P13866 SLC5A1

more at DrugCentral

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