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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PIRTOBRUTINIB
| PIRTOBRUTINIB | ANTINEOPLASTIC | ORAL | Cmax 13.5 MICROMOLAR Tmax 2 HOUR F 85.5 PERCENT VD 32.8 LITER PPB 96 PERCENT Cl 2.02 LITER / HOUR HT 19 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | BTK KINASE PDB 8FLL (CRYSTAL STRUCTURE OF BTK KINASE DOMAIN IN COMPLEX WITH PIRTOBRUTINIB) LIGAND CODE = Y7W (link to the list of PDB complexes) Download experimental 3D coordinates of Y7W with added hydrogens | Tyrosine-protein kinase BTK UNIPROT Q06187 more at DrugCentral | EMA | |||
