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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PHENOBARBITAL
| PHENOBARBITAL | NERVOUS SYSTEM | INTRAVENOUS | Cmax 107.6 MICROMOLAR HT 168 HOUR SOLUBILITY SOLUBLE IN WATER | GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA) PDB 6X3W (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS PHENOBARBITAL) LIGAND CODE = UQA (link to the list of PDB complexes) Download experimental 3D coordinates of UQA with added hydrogens | Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
