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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FUTIBATINIB
| FUTIBATINIB | ANTINEOPLASTIC | ORAL | Cmax 344 NANOMOLAR Tmax 2 HOUR VD 66 LITER PPB 95 PERCENT Cl 20 LITER / HOUR HT 2.9 HOUR SOLUBILITY INSOLUBLE IN WATER | FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FGFR1) FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) PDB 7D5O (C-SRC IN COMPLEX WITH TAS-120) LIGAND CODE = TZ0 (link to the list of PDB complexes) Download experimental 3D coordinates of TZ0 with added hydrogens | Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 more at DrugCentral | EMA | |||
