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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MITAPIVAT
| MITAPIVAT | METABOLISM | ORAL | Cmax 2.1 MICROMOLAR Tmax 0.75 HOUR F 73 PERCENT VD 42.5 LITER PPB 97.7 PERCENT Cl 14.4 LITER / HOUR HT 4 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | PYRUVATE KINASE PDB 8XFD (CRYSTAL STRUCTURE OF PYRUVATE KINASE TETRAMER IN COMPLEX WITH ALLOSTERIC ACTIVATOR, MITAPIVAT (MTPV, AG-348)) LIGAND CODE = WV2 (link to the list of PDB complexes) Download experimental 3D coordinates of WV2 with added hydrogens | Pyruvate kinase PKLR UNIPROT P30613 more at DrugCentral | EMA | |||
