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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GANAXOLONE

GANAXOLONE


ATC N03AX27

NERVOUS SYSTEM
NEUROACTIVE STEROID GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR POSITIVE MODULATOR
TREATMENT OF SEIZURES ASSOCIATED WITH CDKL5 DEFICIENCY DISORDER
ANALOG OF ENDOGENOUS NEUROSTEROID ALLOPREGNANOLONE

ORAL

Tmax 2.5 HOUR

PPB 99 PERCENT

HT 34 HOUR

SOLUBILITY LOW AQUEOUS SOLUBILITY

GABA A

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